NOVEL TREATMENT FOR PATHOLOGIES ASSOCIATED WITH OXIDATIVE DAMAGE

摘要

This invention relates to compositions and methods for the treatment of pathologies associated with intracellular polyamine dysregulation. In particular, the present invention provides compositions and methods involving mammalian polyamine oxidase (PAO) to treat cancer, cell damage, tissue damage caused by ischemia/reperfusion, inflammation, traumatic brain injury, stroke and tissue developmental disorders. Methods for diagnosis and prognosis of cancer and other diseases are also provided by the present invention.