发明名称 |
DE-IMMUNIZED (POLY)PEPTIDE CONSTRUCTS |
摘要 |
The present invention relates to a (poly)peptide construct consisting of at least two domains of at least two pluralities of domains wherein one of said domains or pluralities of domains comprises a de-immunized autoreactive antigen or (a) fragment(s) thereof specifically recognized by the Ig receptors of an autoreactive B-cells and wherein a/the further domain or plurality of domains comprises an effector molecule capable of interacting with and/or of activating NK-cells, T-cells, macrophages, monocytes and/or granulocytes. Preferably, said (poly)peptide construct consisting of at least two domains comprises a de-immunized autoreactive antigen or (a) fragment which is MOG or (a) fragment(s) thereof and a second domain comprising an effector molecule is an anti-CD3 receptor or an Fc-part of an immunoglobulin. The invention also relates to compositions comprising the compounds of the invention. Described is also the use of the afore-mentioned (poly)peptide construct and further compounds for the preparation of a pharmaceutical composition for the treatment and/or prevention of an autoimmune disease. In addition, the present invention relates to method for treating, ameliorating and/or preventing of an autoimmune disease. |
申请公布号 |
WO03068822(A2) |
申请公布日期 |
2003.08.21 |
申请号 |
WO2003EP01389 |
申请日期 |
2003.02.12 |
申请人 |
MICROMET AG;ZOCHER, MARCEL;DREIER, TORSTEN;BAEUERLE, PATRICK |
发明人 |
ZOCHER, MARCEL;DREIER, TORSTEN;BAEUERLE, PATRICK |
分类号 |
A61K38/00;A61K39/39;A61P37/00;C07K14/47;C07K14/705;C07K16/28;C07K19/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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