The present invention provides a novel vaccine expressing a fusion of the measles hemagglutinin (H) protein and the complement component, C3d, to enhance the titers of neutralizing antibody. Plasmids were generated that expressed a secreted (s) form of H and the same form fused to three tandem copies of the murine homologue of C3d (sH-3C3d). Analysis of titers of the antibody raised in vaccinated mice indicated that groups vaccinated with the DNA construct expressing sH-3C3d had higher titers of anti-H antibodies compared to serum from mice vaccinated with DNA expressing sH only. In addition, sH-3C3d elicited higher neutralizing antibody titers that inhibited MV induced plaque formation.
申请公布号
WO03022204(A3)
申请公布日期
2003.08.21
申请号
WO2002US28208
申请日期
2002.09.05
申请人
EAST CAROLINA UNIVERSITY;EMORY UNIVERSITY;ROSS, TED, M.;ROBINSON, HARRIET, L.