A method of improving the efficacy of the treatment with a DNase of a subject having a disorder characterised by the presence of endogenous extracellular DNA, comprises : (a) administering to the subject a glycosaminoglycan or a physiologically acceptable salt thereof, the glycosaminoglycan or salt having an average molecular weight of from 8 to 40kd to the subject; and (b) administering DNase to the subject.
申请公布号
WO03068254(A1)
申请公布日期
2003.08.21
申请号
WO2003GB00668
申请日期
2003.02.14
申请人
UNIVERSITY OF SOUTHAMPTON;SHUTE, JANIS, KAY;CARROLL, MARY, PATRICIA;CONWAY, JOY, HELEN;HOCKEY, PETER, MOREY