OLIGONUCLEOTIDE ANALOGUES AND METHODS OF USE FOR MODULATING GENE EXPRESSION

摘要

The present invention relates generally to oligonucleotide analogues that include novel protein nucleic acid molecules PNAs, particularly monomers, dimers, oligomers thereof and methods of making and using these oligonucleotide analogues. The PNAs of the present invention are characterized as including a variety of classes of molecules, such as, for example, hydroxyproline peptide nucleic acids HypNA, and serine peptide nucleic acids SerNA. The present invention also includes the use of oligonucleotides of the present invention in antisense and homologous recombination constructs and methods.