发明名称 |
Chimeric promoters for controlling expression in muscle cells |
摘要 |
The present invention concerns chimeric constructs comprising a skeletal alpha-actin gene promoter operably linked with at least a skeletal muscle-specific enhancer of a human gene. It also provides an expression cassette comprising such a chimeric construct to control expression of a gene of interest. The invention also relates to a vector, a viral particle, an eukaryotic host cell, a pharmaceutical composition comprising said expression cassette and their use for specific expression in skeletal muscle cells as well as for therapeutic or prophylactic purposes. Finally, the present invention also provides the therapeutic use of an expression cassette, a vector and a viral particle comprising a gene of interest placed under the control of a skeletal alpha-actin gene promoter and a muscle-specific enhancer, especially for treating peripheral ischemia.
|
申请公布号 |
US2003157064(A1) |
申请公布日期 |
2003.08.21 |
申请号 |
US20020290327 |
申请日期 |
2002.11.08 |
申请人 |
NEUVILLE PASCAL;RIBAULT SEBATIEN;CALENDA VALERIE;FRAULI MELANIE |
发明人 |
NEUVILLE PASCAL;RIBAULT SEBATIEN;CALENDA VALERIE;FRAULI MELANIE |
分类号 |
C12N15/09;A61K35/12;A61K35/76;A61K38/17;A61K48/00;A61P9/00;A61P9/10;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N7/00;C12N15/11;C12N15/86;C12N15/861;(IPC1-7):A61K48/00 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|