发明名称 |
MATERIALS AND METHODS FOR PREPARING DIMERIC GROWTH FACTORS |
摘要 |
Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals. |
申请公布号 |
WO03068802(A2) |
申请公布日期 |
2003.08.21 |
申请号 |
WO2003US04213 |
申请日期 |
2003.02.11 |
申请人 |
ZYMOGENETICS, INC. |
发明人 |
FOX, BRIAN, A.;MOORE, MARGARET, D.;SWIDEREK, KRISTINE, M.;BIRKS, CARL, W. |
分类号 |
C12N15/09;A61K38/00;C07K14/49;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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