SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE

摘要

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R~1, R~2, R~3, R~4, and R~5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutica l compositions containing the compounds, methods of preparing the compounds an d methods of treatment using the compounds are also disclosed.