| 摘要 |
Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors preferably inhibit intramembrane proteases, notably aspartyl secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-ß peptide. Methods are provided for making a medicament containing the compounds and for administering the compounds to treat ß-amyloid-associated diseases, notably Alzheimer's disease. |
