Novel endoplasmic reticulum-localized protein, remedies containing the same for diseases associated with glycoprotein abnormality, dna encoding this protein and gene remedies containing the same for treating diseases associated with glycoprotein abnormality

摘要

A protein comprising the amino acid sequence set forth in SEQ ID NO: 1 in the Sequence Listing and a mutant thereof, possessing the glycoprotein production regulating activity, DNA comprising the nucleotide sequence set forth in SEQ ID NO: 2 in the Sequence Listing and a mutant thereof, as well as a therapeutic agent using any of the foregoing for the treatment of glycoprotein aberration disorders (e.g., cystic fibrosis), including gene therapy.