发明名称 |
Smooth muscle cell promoter and uses thereof |
摘要 |
The present invention discloses novel smooth muscle cell specific promoters and uses thereof. The promoters are suited for providing nucleic acid of interest with the capability of expressing specifically in a contractile smooth muscle cell, preferably a vascular contractile smooth muscle cell and/or a visceral contractile smooth muscle cell. One example of such a promoter is a smoothelin gene promoter. For gene therapy purposes said smoothelin gene promoter is preferably derived from a human. A promoter of the invention may be incorporated into nucleic acid delivery vehicle. The nucleic acid delivery vehicle preferably comprises a virus-like particle such as an adenovirus particle, an adeno-associated virus particle or a retrovirus particle.
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申请公布号 |
US2003157494(A1) |
申请公布日期 |
2003.08.21 |
申请号 |
US20020094516 |
申请日期 |
2002.03.08 |
申请人 |
UNIVERSITEIT MAASTRICHT |
发明人 |
VAN EIJS GUILLAUME JOHANNES J. M.;HATEBOER GUUS;HAVENGA MENZO JANS E. |
分类号 |
A61K48/00;C07K14/47;C12N5/08;C12N15/861;(IPC1-7):C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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主权项 |
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地址 |
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