| 摘要 |
The present invention relates to an immediate release formulation with enhanced bio-availability comprising a solid homogeneous and thermostable solution of a poorly water-soluble biologically active substance, characterised in that said solid solution comprises: a the active substance in an amount of between 10 and 50% of the total weight of the formulation, b a non-ionic hydrophilic surfactant ingredient, which is in the liquid form between 15° and 30°C, in an amount of between 20% and 70 % of the total weight of the formulation and c a pharmaceutically acceptable organic polymer or mixture of polymers, which polymer or mixture of polymers is in a liquid form above 60°C and in a solid form below 30°C, in an amount of between 5% and 70% of the total weight of the formulation, and d optionally comprises a disintegrating agent in an amount of between 1% and 10% of the total weight of the formulation. The invention further relates to active substances formulated into the above form and methods for producing the formulation.
|
