MICROFLUIDIC SEPARATION COLUMN DEVICES AND FABRICATION METHODS

摘要

Pressure-driven microfluidic separation devices, such as may be used for performing high performance liquid chromatography, are provided. Multiple separation columns may be defined in a single device and packed with stationary phase material retained by porous frits. One or more splitters ma y be provided to distribute slurry and/or mobile phase among multiple separati on columns. In one embodiment, separation devices are substantially planar and fabricated with multiple device layers. Systems and methods employing slurry for packing separation devices are also provided.