METHODS OF SYNTHESIZING AND USING DERIVATIVES OF [2-(2-AMINOETHOXY)ETHOXY] ACETIC ACID

摘要

A synthetic reaction to produce [2-(2-aminoethoxy)ethoxy] acetic acid (AEEA) derivatives, comprising the steps of: converting 2-(2-(2-chloroethoxy)ethoxy)-ethanol to an azide derivative reacting the azide derivative with triphenylphosphine, followed by reaction with water; adding sodium carbonate and R-Cl to obtain an R-derivative, wherein R is selected from the group consisting of allyloxycarbonyl, fluorenyl-methoxycarbonyl, tertbutyloxycarbonyl, and benzyloxycarbonyl; and oxidizing the R-derivative with 2,2,6,6-tetramethyl-1-piperidinyloxy to give the (2(2-aminoethoxy)ethoxy) acetic acid derivative. This synthetic reaction does not require isolation and purification of intermidiates. The AEEA derivatives can be used to synthesize high load polystyrene-polyethylene glycol-like resins having excellent swelling characteristics.