MEANS AND METHODS FOR ALTERING THE MOTILITY OF THE GASTROINTESTINAL TRACT

摘要

The invention provides a use of a compound capable of at least in part influencing an activity of a neural reflex pathway for the preparation of a medicament for altering the motility of the gastrointestinal tract. Said medicament can be used for prophylaxis and/or treatment of hypomotility of the gastrointestinal tract. Preferably, generalized hypomotility occurring during postoperative ileus is prevented and/or treated by a medicament of the invention.In one aspect of the invention said activity of said neural reflex pathway is decreased by at least in part preventing stimulation of said pathway by an immunocyte, a macrophage and/or a mast cell. Said activity can also be decreased by at least in part preventing immunocyte recruitment. A compound capable of at least in part influencing an activity of a neural reflex pathway for instance comprises an anti-ICAM-1 antibody, an anti LFA-1 antibody, and/or ketotifen. A pharmaceutical composition for prophylactic and/or therapeutic treatment of an individual against hypomotility of the gastro-intestinal tract comprising a compound capable of at least in part decreasing a neural reflex pathway is also herewith provided.