发明名称 |
Method for generating an artificially patterned substrate for stimulating the crystallization of a biomolecule thereon and method of stimulating the crystallization of biomolecules |
摘要 |
It is the aim of the invention to provide a technology for the stimulation of the crystallization of biomolecules contained in a liquid solution that leads to significant improvements in the reliability of crystall growth processes and shortens the time and the number of attempts to grow a certain biomolecule crystal, also under the condition that only very small amounts of the biomolecules are available. This task is solved according to the invention by a method for generating an artificially patterned substrate for stimulating the crystallation of a biomolecule, comprising: a) treating a basic substrate for providing an artificially patterned substrate (4); i) generating said artificially patterned substrate by exposing x-ray-radiation to said basic substrate; ii) performing said exposing of the x-ray-radiation (2) according to X-ray interference lithography technology; With respect to a method for stimulating the crystallization of biomolecules from a liquid solution (20) containing said biomolecules (16, 18), this task is solved according to the invention by a method comprising: a) treating a basic substrate for providing an artificially patterned substrate; i) generating said artificially patterned substrate by exposing x-ray-radiation to said basic substrate; ii) performing said exposing of the X-ray-radiation according to X-ray interference lithography technology; b) bringing said artificially patterned substrate into contact with said solution for initiating the crystallization of said biomolecules on the pattern of the artificially patterned substrate. <IMAGE> |
申请公布号 |
EP1336671(A1) |
申请公布日期 |
2003.08.20 |
申请号 |
EP20020010730 |
申请日期 |
2002.05.14 |
申请人 |
PAUL SCHERRER INSTITUT |
发明人 |
GOBRECHT, JENS, DR.;SOLAK, HARUN, DR.;PADESTE, CELENTINO, DR.;KAMBACH, CHRISTIAN, DR. |
分类号 |
C07K1/30;C30B7/00;G03F7/00 |
主分类号 |
C07K1/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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