发明名称 |
POLO DOMAIN STRUCTURE |
摘要 |
The present invention relates to binding pockets of a polo domain. In particular, the invention relates to a crystal comprising a binding pocket of a polo domain. The crystal may be useful for modeling and/or synthesizing mimetics of a binding pocket or ligands that associate with the binding pocket. Such mimetics or ligands may be capable of acting as modulators of polo family kinases, and they may be useful for treating, inhibiting, or preventing diseases modulated by such kinases.
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申请公布号 |
CA2372412(A1) |
申请公布日期 |
2003.08.19 |
申请号 |
CA20022372412 |
申请日期 |
2002.02.19 |
申请人 |
MOUNT SINAI HOSPITAL |
发明人 |
DENNIS, JIM;SICHERI, FRANK;LEUNG, GENIE CHUNG CHI;HUDSON, JOHN;KOZAROVA, ANNA |
分类号 |
C12N9/12;(IPC1-7):C07K14/47;C07K17/00;C12N9/10;A61K35/12 |
主分类号 |
C12N9/12 |
代理机构 |
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