Pyrimidine derivatives, process for preparing the derivatives and drugs containing the same as the active ingredient.

摘要

A pyrimidine compound of formula (I), wherein R<1> is H, F; R<2> is -CH(OR<3>)2, t-butoxycarbonyl, -CH=CH2, furan-2-yl, -CHO, -COOH or a group of formula (II); R<3> is methyl or ethyl; R<4> is methyl, isopropyl, n-butyl, t-butyl, phenyl, 1-methylcyclopropyl, benzyl, 3-methylbenzyl, 3-trifluoromethylbenzyl, 3,4-methylenedioxybenzyl, alpha , alpha -dimethylbenzyl, alpha , alpha -dimetyl-3-methylbenzyl, alpha , alpha -dimetyl-3-trifluoromethylbenzyl or alpha , alpha -dimetyl-3,4-methylenedioxybenzyl; or a non-toxic salt thereof. A pyrimidine compound of formula (I) or a non-toxic salt thereof is useful as an important intermediate of pharmaceutical compound and/or a pharmaceutical, especially elastase inhibitor.