| 摘要 |
PROBLEM TO BE SOLVED: To provide a stable omeprazole-containing pharmaceutical preparation in which decomposition and discoloration are suppressed over a long period. SOLUTION: The solid pharmaceutical preparation is obtained by coating a nucleic composition comprising omeprazole or its salt and a buffer composed of a coprecipitate of a polyvalent metal hydroxide and a carbonic metal salt with at least one kind of enteric polymer selected from cellulosecarboxyalkyl ethers and (meth)acrylic polymers. The buffer may be composed of a coprecipitate of aluminium hydroxide and a carbonic metal alkali salt (particularly a coprecipitate of aluminium hydroxide and sodium hydrogancarbonate). The enteric polymer may be composed of a carboxymethyl-1-4C alkylcellulose, a methacrylic acid-acrylic 1-4C alkyl ester, or the like. The nucleic composition may further contain a basic amino acid or its salt. COPYRIGHT: (C)2003,JPO
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