发明名称 |
Heterologous G protein coupled receptors expressed in yeast, their fusion with G proteins and use thereof in bioassay |
摘要 |
A first aspect of the present invention is directed to a transformed yeast cell containing a first heterologous DNA sequence which codes for a G protein-coupled receptor, for example, the somatostatin receptor, and a second heterologous DNA sequence which codes for a G protein a subunit or portions thereof fused to DNA sequences from the yeast G protein in a subunit. A second aspect of the present invention is a transformed yeast cell containing a heterologous DNA sequence which codes for a G protein coupled receptor. A third aspect of the present invention is a method of assaying compounds to determine effects on cell growth.
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申请公布号 |
US6607906(B1) |
申请公布日期 |
2003.08.19 |
申请号 |
US19980057473 |
申请日期 |
1998.04.09 |
申请人 |
BASF AKTIENGESELLSCHAFT |
发明人 |
PAUSCH MARK HENRY;OZENBERGER BRADLEY ALTON;HADCOCK JOHN RICHARD;PRICE LAURA ALICIA;KAJKOWSKI EILEEN MARIE;KIRSCH DONALD RICHARD;CHALEFF DEBORAH TARDY |
分类号 |
C12N15/09;C07K14/72;C12N1/15;C12N1/19;C12N15/12;C12P21/02;C12Q1/02;C12R1/865;(IPC1-7):G01N33/569;G01N33/566;C12N1/20 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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