发明名称 |
Process for preparing an oral osomotic controlled drug delivery system for a sparingly soluble drug |
摘要 |
<p>The present invention is for an oral osmotic controlled drug delivery system for a sparingly soluble drug comprising:a. a core comprising (i) finely particulate anhydrous carbamazepine (ii) a polymeric swelling agent consisting of one or more swellable hydrophilic polymers selected such that the polymeric swelling agent exhibits controlled swelling and the wall does not rupture or burst, (iii) a crystal habit modifier in whose presence, upon contact with an aqueous medium, the anhydrous carbamazepine being transformed into cuboidal or rod-shaped crystals of the dihydrate of carbamazepine, or mixtures thereof, and (iv) water-soluble compounds for inducing osmosis,b. a wall made of acylated cellulose which is impermeable to the components of the core, but permeable to water, andc. a passageway through the wall for releasing the components present in the core to the surrounding environment.</p> |
申请公布号 |
IN190699(B) |
申请公布日期 |
2003.08.16 |
申请号 |
IN2001MU00119 |
申请日期 |
2001.02.02 |
申请人 |
SUN PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
DHARMADHIKARI, NITIN BHALACHANDRA, DR.;SHRIVASTAVA, RATNESH HARINARAYAN, DR.;PILGAONKAR, PRATIBHA, S.;PUTHLI, SHIVANAND PREMANAND, DR.;MENON SUMA GIRISH;KARAJGI, JAYANT SHRIKANT, DR. |
分类号 |
A61K9/00;(IPC1-7):A61J3/00;A61J3/07 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|