NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED STEAP-1 USEFUL IN TREATMENT AND DETECTION OF CANCER

摘要

A novel gene 08P1D4 (also designated STEAP-l) and its encoded protein, and variants thereof, are described wherein STEAP-l exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-l provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer, The STEAP-l gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-l can be used in active or passive immunization.