11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS USEFUL FORTHE TREATMENT OF DIABETES, OBESITY AND DYSLIPIDEMIA

摘要

Compounds having Formula (I), including pharmaceutically acceptable salts and prodrugs thereof: are selective inhibitors of the 11.beta.-HSD1 enzyme. They inhibit the 11.beta.-HSD1-mediated conversion of cortisone and other 11-keto- glucocorticoids to cortisol and other 11.beta.-hydroxy-glucocorticoids. The 11.beta.-HSD1 inhibitors therefore decrease the amount of cortisol in target tissues, thereby modulating the effects of cortisol. Modulation of cortisol may be effective in controlling non-insulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Syndrome X, and other symptoms associated with NIDDM or with excess cortisol in the body.