发明名称 |
RETROVIRAL VECTORS PSEUDOTYPED WITH INFLUENZA VIRUS HEMAGGLUTININ FOR GENE DELIVERY |
摘要 |
A retroviral delivery system capable of transducing a target site is described. The retroviral delivery system comprises a first nucleotide sequence coding for at least a part of an envelope protein; a second nucleotide sequence coding for at least a part of an envelope protein and one or more other nucleotide sequences derivable from a retrovirus that ensure transduction of the target site by the retroviral delivery system; wherein the first and second nucleotide sequences are heterologous with respect to at least one of the other nucleotide sequences; and wherein the first nucleotide sequence codes for at least a part of an influenza HA protein or a mutant, variant, derivative or fragment thereof that is capable of recognising the target site. Preferably said second protein is an influenza M2 protein.
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申请公布号 |
WO03066868(A1) |
申请公布日期 |
2003.08.14 |
申请号 |
WO2003GB00496 |
申请日期 |
2003.02.04 |
申请人 |
OXFORD BIOMEDICA (UK) LIMITED;UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;OLSEN, JOHN, CHRISTIAN |
发明人 |
OLSEN, JOHN, CHRISTIAN |
分类号 |
A61K48/00;C12N5/10;C12N7/00;C12N15/86;C12N15/867;(IPC1-7):C12N15/86 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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