发明名称 |
Methods for altering polyketide synthase genes |
摘要 |
Ketoreductase (KR) domains of modular polyketide synthase (PKS) enzymes can be inactivated by one or more point mutations in the domain. Replacement or insertion of a KR domain can be used to introduce a cis or trans double bond into a polyketide by appropriate selection or inactivation of the type of KR domain that codes for a particular stereochemical configuration of a hydroxyl moiety. Inactivation of a DH domain can be used to produce a polyketide having a hydroxyl moiety with a desired stereochemical configuration.
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申请公布号 |
US2003153053(A1) |
申请公布日期 |
2003.08.14 |
申请号 |
US20020214424 |
申请日期 |
2002.08.06 |
申请人 |
REID RALPH |
发明人 |
REID RALPH |
分类号 |
C12N1/21;C12N15/52;(IPC1-7):C12P19/62;C12N9/10;C12P21/02;C12N15/74 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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