发明名称 |
PROCESS FOR REMOVING PROTEIN AGGREGATES AND VIRUS FROM A PROTEIN SOLUTION |
摘要 |
A process is provided for selectively removing protein aggregates from a protein solution in a normal flow (NFF) filtration process. Preferably, it relates to a process for selectively removing protein aggregates from a protein solution in a normal flow (NFF) filtration process and virus particles from a protein solution in a two-step filtration process. In a first step, a protein solution is filtered through one or more layers of adsorptive depth filters, charged or surface modified microporous membranes or a small bed of chromatography media in a normal flow filtration mode of operation, to produce a protein aggregate free stream. The aggregate free protein stream can then be filtered through one or more ultrafiltration membranes to retain virus particles at a retention level of at least 3 LRV and to allow passage therethrough of an aggregate free and virus free protein solution. |
申请公布号 |
WO03066669(A2) |
申请公布日期 |
2003.08.14 |
申请号 |
WO2003US03269 |
申请日期 |
2003.02.04 |
申请人 |
MILLIPORE CORPORATION |
发明人 |
SIWAK, MARTY;AN, HONG;CORMIER, JASON R.;KINZLMAIER, DANA |
分类号 |
B01D61/14;B01D61/16;C07K1/34;C07K1/36 |
主分类号 |
B01D61/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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