摘要 |
Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vivo. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.
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申请人 |
THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON;THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;UNIVERSITY OF SOUTHERN CALIFORNIA;UNIVERSITY OF MIAMI;SELKER, ERIC, U.;MATSEN, CINDY, B.;GREER, SHELDON, B.;JONES, PETER, A.;CHENG, JONATHAN;MARQUEZ, VICTOR, E. |
发明人 |
SELKER, ERIC, U.;MATSEN, CINDY, B.;GREER, SHELDON, B.;JONES, PETER, A.;CHENG, JONATHAN;MARQUEZ, VICTOR, E. |