发明名称 |
GAMMA SECRETASE INHIBITORS |
摘要 |
This invention discloses novel gamma secretase inhibitors of the formula:(Chemical formula should be inserted here as it appears on abstract in paper form)wherein: R1 is a substituted aryl or substituted heteroaryl group ; R2 is an R1 group, alkyl, -X(CO)Y, or alkylene-X(CO)Y wherein X and Y are as defined herein; each R3 and each R3A are independently H, or alkyl; R11 is aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. Also disclosed is a method of treating Alzheimer s Disease using one or more compounds of the invention.
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申请公布号 |
CA2478423(A1) |
申请公布日期 |
2003.08.14 |
申请号 |
CA20032478423 |
申请日期 |
2003.02.05 |
申请人 |
SCHERING CORPORATION;PHARMACOPEIA DRUG DISCOVERY, INC. |
发明人 |
SMITH, ELIZABETH M.;HOBBS, DOUGLAS W.;JOSIEN, HUBERT B.;GUO, TAO;CLADER, JOHN W.;PISSARNITSKI, DMITRI A.;ASBEROM, THEODROS |
分类号 |
C07D491/113;A61K31/445;A61K31/4535;A61K31/454;A61K31/4545;A61K31/4709;A61K31/4725;A61K31/496;A61K31/5377;A61K31/541;A61K31/55;A61K31/551;A61P25/18;A61P25/28;A61P43/00;C07D211/96;C07D401/04;C07D401/12;C07D401/14;C07D405/14;C07D409/12;C07D413/12;C07D413/14;C07D417/14;C07D471/10;(IPC1-7):C07D211/96;A61K31/442 |
主分类号 |
C07D491/113 |
代理机构 |
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