发明名称 |
Monoclonal antibodies to the fibronectin binding protein and method of use in treating or preventing infections |
摘要 |
Monoclonal antibodies which can bind to the Fnbp protein of Staphylococcus aureus and which are generated from a peptide from the D2 region of fibronectin binding protein B (Fnbp) of S. aureus are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus aureus. The monoclonal antibodies of the invention are advantageous in that they bind S. aureus in high affinity and thus can be useful in the prevention of the adherence of staph bacteria to host cells by impairing or inhibiting the ability of S. aureus Fnbp to bind to fibronectin. Kits and methods of utilizing the monoclonal antibodies of the invention are also provided.
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申请公布号 |
US2003153022(A1) |
申请公布日期 |
2003.08.14 |
申请号 |
US20020287821 |
申请日期 |
2002.11.05 |
申请人 |
PATTI JOSEPH M.;PATEL PRATISKSHA;HALL ANDREA;DOMANSKI PAUL;SYRIBEYS PETER;HUTCHINS JEFF T. |
发明人 |
PATTI JOSEPH M.;PATEL PRATISKSHA;HALL ANDREA;DOMANSKI PAUL;SYRIBEYS PETER;HUTCHINS JEFF T. |
分类号 |
C07K16/12;(IPC1-7):G01N33/569 |
主分类号 |
C07K16/12 |
代理机构 |
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主权项 |
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地址 |
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