发明名称 Bh4-fused polypeptides
摘要 A BH4 fusion polypeptide comprising an amino acid sequence of a polypeptide capable of exhibiting uptake action into a cell or a derivative sequence thereof; and an amino acid sequence selected from the group consisting of (A) an amino acid sequence comprising at least the sequence of BH4 domain (SEQ ID NO: 1) of anti-apoptotic Bcl-2 family protein, (B) an amino acid sequence having substitution, deletion or insertion of at least one amino acid residue in the amino acid sequence of SEQ ID NO: 1, and (C) an amino acid sequence having at least 50% sequence identity to the amino acid sequence of SEQ ID NO: 1, wherein the BH4 fusion polypeptide is capable of inhibiting apoptosis; an apoptosis-inhibitor comprising the BH4 fusion polypeptide mentioned above; a method for treating an ischemic disease, characterized by administering the apoptosis-inhibitor mentioned above to a patient with the ischemic disease to inhibit apoptosis, thereby treating the ischemic disease; and use of the BH4 polypeptide mentioned above, for manufacturing a prophylactic or therapeutic agent for an ischemic disease. According to the present invention, the apoptosis can be efficiently suppressed, so that its application as a therapeutic agent for AIDS, neurodegenerative disorders, osteomyelodysplasia, ischemic diseases, infectious multiple organ failure, fulminant hepatitis, diabetes and the like can be expected.
申请公布号 US2003152946(A1) 申请公布日期 2003.08.14
申请号 US20020169223 申请日期 2002.06.27
申请人 SHIMIZU SHIGEOMI;TSUJIMOTO YOSHIHIDE 发明人 SHIMIZU SHIGEOMI;TSUJIMOTO YOSHIHIDE
分类号 A61K38/00;A61P9/10;C07K14/47;C12N15/12;(IPC1-7):C12Q1/68;C07H21/04;C12N9/99;C12P21/02;C12N5/06 主分类号 A61K38/00
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