发明名称 |
SYNTHESIS OF SULFAMIDATES |
摘要 |
A regio- and stereoselective two-stage synthesis of beta-aminoalcohols employs a key transformation, viz., the creation of a cyclic sulfamidate from a precursor diol, mediated by Burgess-type reagents. The generality and scope of this approach is underscored by the considerable number and variety of substrates which display high levels of selectivity in the process. As such, this method provides facile access to compounds for use in myriad applications, whether as chiral ligands to perform asymmetric synthesis or as molecular probes to explore problems in chemical biology. |
申请公布号 |
WO03066549(A2) |
申请公布日期 |
2003.08.14 |
申请号 |
WO2003US03788 |
申请日期 |
2003.02.07 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE;NICOLAOU, KYRIACOS, C.;SNYDER, SCOTT. A;HUANG, XIANHAI |
发明人 |
NICOLAOU, KYRIACOS, C.;SNYDER, SCOTT. A;HUANG, XIANHAI |
分类号 |
C07C269/06;C07C271/16;C07C307/06;C07D291/04;C07D419/14 |
主分类号 |
C07C269/06 |
代理机构 |
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代理人 |
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地址 |
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