CRYSTALLIZED PPAR DOLLAR G(A) LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME

摘要

A solved three-dimensional crystal structure of a PPAR alpha ligand binding domain polypeptide is disclosed, along with a crystal form of the PPAR alpha ligand binding domain polypeptide. Methods of designing modulators of the biological activity of PPAR alpha and other PPAR ligand binding domain polypeptides are also disclosed.