DIPEPTIDES AND TRIPEPTIDES WITH ANTI-INFLAMMATORY ACTIVITY

摘要

Methods for inhibiting an inflammatory reaction in a mammal and pharmaceutic al compositions are provided. The methods comprise administering to the mammal an effective amount of a peptide of the formula: X1 - X2 - X3 wherein X1 is selected from the group consisting of 2-amino-hexanoic acid; 2-amino-heptano ic acid; 2-amino-octanoic acid; cyclohexyl-substituted 2-amino-ethanoic acid, 2 - amino-propanoic acid or 2-amino-butanoic acid and methionine; X2 is an acidi c amino acid; and X3 is an aliphatic amino acid; or of a peptide of the formul a: X4 - X5 wherein X4 is an aromatic or aliphatic amino acid; and X5 is an acid ic amino acid.