IMMUNOGENIC FORMULATIONS OF VARIABLE PEPTIDIC EPITOPES AND PROCESS FOR PREPARATION THEREOF

摘要

A process is disclosed for preparation of a immunogenic peptide mixture in a single synthesis. The peptide mixture collectively represents the in vivo variability seen in immunogenic epitopes from a pathogen. The mixture is termed a hypervariable epitope construct (HEC). Immunization with a HEC evokes broadly reactive immunity against divergent strains of a pathogen upon which the HEC is based.