发明名称 |
COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASES AND DISORDERS, AND FOR IDENTIFYING AGENTS THERAPEUTIC THEREFOR |
摘要 |
Methods and compositions are disclosed that are useful for the prevention and/or treatment of cardiovascular and cardiac diseases and disorders, or damage resulting from surgical or medical procedures that may cuase ischemic or ischemic/reperfusion damage in humans; and cardiovascular trauma. The beneficial effects of the compositions and methods are achieved through the use of pharmaceutical compositions that include agents that interfere with the production and/or biological activities of sphingolipids and their metabolites, particularly sphingosine (SPH) and sphingosine-1-phosphate (S-1-P). Also disclosed are methods for identifying and isolating therapeutic agents. |
申请公布号 |
WO02051439(A3) |
申请公布日期 |
2003.08.14 |
申请号 |
WO2001US50785 |
申请日期 |
2001.12.21 |
申请人 |
MEDLYTE, INC.;SABBADINI, ROGER, A. |
发明人 |
SABBADINI, ROGER, A. |
分类号 |
A61K31/7036;A61K38/17;A61P9/00;C07K14/705;C07K16/18;C07K16/28;C12N9/12;C12N9/80;G01N33/68;G01N33/92 |
主分类号 |
A61K31/7036 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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