| 摘要 |
<p>Aromatic amino acid derivatives represented by the following general formula (I) or pharmacologically acceptable salts thereof: (I) wherein R1 represents hydrogen or an amino-protecting group; R2 represents hydrogen, alkylaralkyl or aryl; R3 represents (1) halogeno, (2) aroylamino, (3) phenyl substituted by lower alkyl, phenyl, phenoxy, etc., (4) naphthyl or tetrahydronaphthyl optionally substituted by hydroxy, lower alkoxy or di(lower alkyl)amino, (5) an N-, O- and/or S-containing unsaturated monocyclic heterocycle group substituted by lower alkyl, phenyl, naphthyl or tetrahydroquinolyl, or (6) an N-, O- and/or S-containing fused heterocycle group, which may be unsaturated or partly saturated, optionally substituted by oxo, carboxy, amino, lower alkyl, etc.; X represents halogeno, alkyl or alkoxy; Y represents oxygen or nitrogen; l is 0 or 1; m is 0, 1 or 2; and n is an integer of from 0 to 5. These compounds inhibit a transporter (LAT1) of essential amino acids which are one of the main nutrients for cancer cells and induce depletion of the essential amino acids in the cancer cells, thereby inhibit the proliferation of the cancer cells.</p> |
