NOVEL PYRANOSYL CYTOSINES: PHARMACEUTICAL FORMULATIONS AND METHODS
摘要
This invention is directed to novel pyranosyl cytosine compounds depicted graphically as structure I. This invention is further directed to a unique methodology for their preparation using solid-phase methodology. These hexopyranosyl cytosine derived natural product analogs share their parent compounds broad-spectrum antimicrobial and anti-fungal profile and represent a vast, novel compound class of 50S rRNA directed inhibitors of protein translation. (I)
申请公布号
WO03066633(A1)
申请公布日期
2003.08.14
申请号
WO2003US03191
申请日期
2003.02.04
申请人
ISIS PHARMACEUTICALS, INC.;MIGAWA, MICHAEL, T.;SWAYZE, ERIC, E.;GRIFFEY, RICHARD, H.
发明人
MIGAWA, MICHAEL, T.;SWAYZE, ERIC, E.;GRIFFEY, RICHARD, H.