PIPERIDYLCARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF TACHYKINIM-MEDIATED DISEASES

摘要

The present invention relates to piperidine derivatives of formula I wherein R represents halogen or C1-4 alkyl R1 represents hydrogen or C1-4 alkyl R2 represents hydrogen , C1-4 alkyl or R2 together with R3 represents C3-7 cycloalkyl R3 represents hydrogen, C1-4 alkyl, C3-7 cycloalkyl or C3-6 alkenyl or R1 and R3 together with nitrogen and carbon atom to which they are attached respectively represent a 5 to 6 membered heterocyclic group R4 represents trifluoromethyl, C1-4 alkyl, C1-4 alkoxy, trifluoromethoxy or halogen R is hydrogen and R is NR7R8 or R5 is NR8R9 and R6 is hydrogen R7 represents hydrogen or C1-4 alkyl or R7 and R8 together with nitrogen to which they are attached are a saturated 5 to 7 membered heterocyclic group containing oxygen R8 represents hydrogen, phenyl, C3-7 cycloalkyl, CH2pCONR10R11, a saturated 5 to 7 membered heterocyclic group containing 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen and optionally substituted by C1-4 alkyl, SO2C1-4 alkyl or CO C1-4 alkyl, a 5 membered heteroaryl group containing 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen and optionally substituted by C1-4 alkyl SO2C1-4 alkyl or CO C1-4 alkyl or R8 represents a 6 membered heteroaryl group containing 1 to 3 nitrogen atoms and optionally substituted by C1-4 alkyl, SO2C1-4 alkyl or CO C1-4 alkyl or R8 is a C1-6 alkyl group optionally substituted by one or two groups selected from fluorine, phenyloptionally substituted by C1-4 alkyl, CO C1-4 alkyl or halogen, =O, C3-7 cycloalkyl, hydroxy, amino, dimethylamino, aminocarbonyl, C1-4 alkoxy or trifluoromethyl R9 is hydrogen, C1-4 alkyl or R9 and R8 together with nitrogen to which they are attached are a 5 to 7 membered heterocyclic group optionally containing another heroatom selected from oxygen, sulphur and nitrogen and optionally substituted by one or two groups selected from C1-4 alkyl, =O, SO2C1-4 alkyl, CO C3-7 cycloalkyl or CO C1-4 alkyl R10 and R11 are independently hydrogen or C1-4 alkyl group X represents a nitrogen atom and Y is CH or X represents CH and Y is nitrogen