摘要 |
<p>In the present invention, there is disclosed a process for preparing sertraline by reducing amination of a racemic 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)naphthalenone. The preparation process is carried out in a single reaction vessel without isolation of intermediates, in the form of pure cis and trans geometric isomers being separated from each other. Disclosed is also a conversion process of trans isomer to cis-isomer, as well as preparation process of cis isomer polymorph 1S from any other polymorph.</p> |