| 摘要 |
In the present invention there is disclosed a process for the preparation of a compound having the structural formula II, which process comprises the steps of: (a) cyclizing a diacid of the structural formula 9 or an activated form thereof, with benzylamine to provide a dione derivative of structural formula 16, (b) reducing the product of step (a) to provide an isoquinoline derivative of structural formula 17, (c) reducing the product of step (b) to provide an amino derivative of structural formula 18, (d) coupling the product of step (c) with the compound 4'-trifluoromethylbiphenyl-2-carboxylic acid, or an activated form thereof to provide an amide derivative of structural formula 19, (e) deprotecting the amide derivative of step (d) to provide said amino derivative of structural formula II, and (f) isolating the amino derivative of step (e) in the free base form or in the form of acid addition salt. Claimed is also the compound of the general formula A wherein R represents the group -NOi2 or -NHi2; or acid addition salt thereof. |
