| 摘要 |
<p>What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.</p> |
| 申请人 |
VIROGENETICS CORPORATION |
发明人 |
PAOLETTI, ENZO;PERKUS, MARION E.;TAYLOR, JILL;TARTAGLIA, JAMES;NORTON, ELIZABETH, K.;RIVIERE, MICHEL;DE TAISNE, CHARLES;LIMBACH, KEITH, J.;JOHNSON, GERARD, P.;PINCUS, STEVEN, E.;COX, WILLIAM, I.;FRANCIS, JEAN-CHRISTOPHE;GETTIG, RUSSELL, ROBERT |
