发明名称 |
ERYTHROMYCIN DERIVATIVE HAVING NOVEL CRYSTAL STRUCTURES AND PROCESSES FOR THEIR PRODUCTION |
摘要 |
The present invention provides an E-type crystal of N-demethyl-N-isopropyl-12-methoxy-11-oxo-8,9-anhydroerythromycin A-6,9-hemiacetal fumarate having strong diffraction peaks at diffraction angles (2&thetas;) of 5.6 DEG and 10.4 DEG as measured by powder X-ray diffractometry, which is prepared by treating a C-type crystal of the compound in a mixed solvent of ethyl acetate and water at 20 DEG C to 40 DEG C, and a D-type crystal prepared via the E-type crystal. These crystals have a reduced content of residual solvent and high suitability for formulation. <IMAGE>
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申请公布号 |
EP1334726(A1) |
申请公布日期 |
2003.08.13 |
申请号 |
EP20010974825 |
申请日期 |
2001.10.12 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
HIRAIDE, AKIRA;KOYAMA, KAICHIRO;SHIMIZU, HITOSHI;TSUZAKI, KANAME |
分类号 |
A61K31/351;A61K31/7048;A61P1/00;C07H17/08;(IPC1-7):A61K31/704 |
主分类号 |
A61K31/351 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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