发明名称 Tyrosine derivatives with anti-leukotriene activity
摘要 Compounds which can be represented by general formula (I) indicated below and in which:R1 and R2 are selected, independently, from hydrogen, an alkyl group having from 1 to 4 carbon atoms, a halogen group such as a fluoro, chloro or bromo group, the methoxy group, the cyano group, or the trifluoromethyl group, andR3 is selected, independently, from a phenyl or a 2 (or 3 or 4)-pyridyl group, unsubstituted or mono- or di-substituted with an alkyl or alkoxy group having from 1 to 4 carbon atoms, with a halogen group such as a fluoro or chloro group, with the trifluoromethyl group, with the cyano group, with the nitro group, with the amino group, or with the phenyl group, a 1 (or 2)-naphthyl group, a 2 (or 3)-indolyl group as such or N-alkylated with an alkyl group having from 1 to 3 carbon atoms, a 2 (or 3, 4, 5, 6, 7 or 8)-quinolinyl or a 1 (or 3, 4, 5, 6, 7 or 8)-isoquinolinyl group, unsubstituted or mono- or di-substituted with a group selected, independently, from the methyl, ethyl, propyl, isopropyl, methoxy, fluoro, chloro, trifluoromethyl, cyano, amino, or nitro groups, a 2 (or 5 or 6)-quinoxalyl group, a (or 4, 5, 6, 7 or 8) cinnolyl group, or a 2 (or 4, 5, 6 or 7)-benzimidazolyl group, and in which the configuration of the chiral centre marked with an asterisk (*) in the general formula (I) may be, independently, L, D or DL (racemic).
申请公布号 US6605722(B2) 申请公布日期 2003.08.12
申请号 US20020203424 申请日期 2002.08.08
申请人 ROTTA RESEARCH LABORATORIUM S.P.A. 发明人 MAKOVEC FRANCESCO;PERIS WALTER;ROVATI LUCIO CLAUDIO
分类号 C07D215/54;A61K9/12;A61K31/4709;A61K31/4725;A61K31/498;A61K31/501;A61P1/00;A61P1/04;A61P9/00;A61P9/10;A61P11/00;A61P11/02;A61P11/06;A61P27/02;A61P27/14;A61P29/00;A61P37/08;A61P43/00;C07D215/14;C07D215/18;C07D401/12;(IPC1-7):C07D215/38;C07D215/12;A61K31/47 主分类号 C07D215/54
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