Synthetic method of alpha-ketol unsaturated fatty acids

摘要

The present invention provides an efficient synthetic method of alpha-ketol unsaturated fatty acid having a double bond at a beta-position to the ketone group thereof. It comprises the steps of: preparing compound (4) by reacting monosubstituted acetylene (2) with epoxide (3); and preparing alpha-ketol unsaturated fatty acid (1) from said compound (4) as shown in Reaction Formula 1:wherein R1 represents an alkyl group of 1-18 carbon atoms or an aliphatic hydrocarbon group of 2-18 carbon atoms having 1-5 double or triple bonds at given positions; R2 represents a protecting group for a hydroxyl group; R3 represents a protecting group for a carboxyl group; R is identical to R1 or, when R1 has one or more triple bonds, represents an aliphatic hydrocarbon group in which each triple bond of R1 is converted to a double bond; and A represents an alkylene group of 1-18 carbon atoms.