发明名称 |
Media milling |
摘要 |
This invention describes a process for preparing a dispersion of solid particles of a milled substrate in a fluid carrier comprising the steps of (a) providing a plurality of large size milling media to the milling chamber of a media mill and forming a depth filter therefrom on an exit screen or separator in the milling chamber; (b) adding to said milling chamber a plurality of small size milling media optionally containing additional large size milling media, a conglomerate of a solid substance comprising a substrate to be milled and optionally one or more than one surface active substance, and a fluid carrier; (c) milling said conglomerate in said milling chamber to produce very small milled substrate product particles; and (d) separating said milled substrate particles suspended in said fluid carrier from the media through said depth filter; wherein the exit screen comprises openings of size S0; the large size media have a size distribution S1 of which all are larger than S0; the small size media have a size distribution S2 which are smaller than S0; the very small milled substrate particles have a size distribution S3 and are smaller than all of the small media; and the large size media and the small size media are essentially retained in the milling chamber.
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申请公布号 |
US6604698(B2) |
申请公布日期 |
2003.08.12 |
申请号 |
US20010852054 |
申请日期 |
2001.05.10 |
申请人 |
SKYEPHARMA CANADA, INC. |
发明人 |
VERHOFF FRANK H.;SNOW ROBERT A.;PACE GARY W. |
分类号 |
A61K9/10;A61K8/00;A61K8/24;A61K8/31;A61K8/34;A61K8/42;A61K8/46;A61K8/86;A61K9/14;A61K31/216;A61K45/00;A61K47/02;A61K47/04;A61K47/06;A61K47/10;A61K47/16;A61K47/20;A61K47/24;A61K47/26;A61K47/30;A61K47/34;A61K47/36;A61Q90/00;B02C17/16;(IPC1-7):B02C17/16;B02C19/12 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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