摘要 |
The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general formula (1) corresponding to general sub-formulae (I)<SUB>1 </SUB>and (I)<SUB>2</SUB>, wherein: R<SUB>1 </SUB>represents H, SR<SUB>4 </SUB>or NR<SUB>4</SUB>R<SUB>5</SUB>; R<SUB>2 </SUB>represents SR<SUB>6 </SUB>or NR<SUB>6</SUB>R<SUB>7</SUB>; R<SUB>3 </SUB>represents OH, O(CO)R<SUB>14</SUB>, OSiR<SUB>15</SUB>R<SUB>16</SUB>R<SUB>17</SUB>, O(CO)OR<SUB>18 </SUB>or O(CO)NHR<SUB>18</SUB>, each of the radicals R<SUB>4</SUB>, R<SUB>6</SUB>, R<SUB>15</SUB>, R<SUB>16 </SUB>and R<SUB>17 </SUB>representing independently (in particular) an alkyl radical, the radicals R<SUB>5 </SUB>and R<SUB>7 </SUB>representing (in particular) radicals selected independently among a hydrogen atom and an alkyl radical, and each of the radicals R<SUB>14 </SUB>and R<SUB>18 </SUB>representing independently (in particular) an alkyl or cycloalkyl radical, or one among aryl, heteroaryl, aralkyl or heteroalkyl radicals optionally substituted; provided that when the compounds correspond to the general sub-formula (I)<SUB>2</SUB>, then R<SUB>1 </SUB>does not represent a hydrogen atom |