发明名称 IMMUNE SUPPRESSIVE AGENT
摘要 PURPOSE: A pharmaceutical composition containing a therapeutically effective amount of diterpene derivatives is provided. The composition inhibits NFAT functions as a transcription factor involved in inflammation and thus can be used as a prophylactic and therapeutic agent for prevention and treatment of inflammation such as arthritis. CONSTITUTION: The pharmaceutical composition contains diterpene derivatives represented by the formula 1. In formula, R is imidazolylcarbonyl, 2,5-dioxooxazolidine-3-ylcarbonyl, methoxymethyl, methoxybenzyloxymethyl, tetrahydro-pyranoxy methyl, hydroxy methylvinyl, imidazolylcarbovinyl, imidazolylcarboethyl, hydroxypropanyl, methoxypropanyl, methoxy benzyloxy propanyl, tetrahydro-pyranoxy propanyl, hydroxymethylaryl, imidazolyl carbo-aryl, hydroxy butanyl, imidazolyl carbo-propanyl, dimethyl hydroxy methylvinyl, dimethyl hydroxy methyl ethyl, dimethyl hydroxy propanyl, thiomethyl, tertiary butoxy carbamyl, ethoxy carbamyl or amino.
申请公布号 KR20030066026(A) 申请公布日期 2003.08.09
申请号 KR20020006173 申请日期 2002.02.04
申请人 NA, DOE SUN;PHARM TECH RESEARCH INCORPORATION;SUH, YOUNG GEU 发明人 KIM, AE YEONG;KIM, JEONG U;KIM, SEOK HO;KIM, YEONG HO;LEE, MI SEON;LIM, JONG SEOK;NA, DOE SUN;SUH, YOUNG GEU
分类号 A61K31/421;(IPC1-7):A61K31/421 主分类号 A61K31/421
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