Oligonucleotides antisense to rat pituitary tumor transforming gene carboxy-terminal (PTTG-C) and methods of use thereof to inhibit neoplastic cellular proliferation and/or transformation

摘要

Disclosed is a method of inhibiting neoplastic cellular proliferation and/or transformation of mammalian cells, including cells of human origin, in vitro or in vivo. The inventive method involves the delivery of polynucleotides antisense to PTTG-C-related polynucleotides to mammalian cells, whether in vitro or in vivo, to inhibit the endogenous expression of PTTG. Also disclosed are compositions comprising antisense PTTG carboxy-terminal-related polynucleotides, including compositions comprising expression vectors containing the PTTG-C-related polynucleotides. Kits comprising the inventive compositions are also disclosed for the treatment of neoplastic cellular proliferation in vitro or in vivo.