发明名称 |
Biodegradable multi-block copolymers of poly(amino acid)s and poly(ethylene glycol) for the delivery of bioactive agents |
摘要 |
This patent discloses the synthesis of a multi-block copolymer containing poly(amino acids) (PAA) and a hydrophilic polymer which are degradable under physiological conditions. Control over the degradation rate of the obtained copolymers is achieved by introducing ester, amide or urethane groups as a biodegradable linkage connecting the PAA and the hydrophilic polymer. The biodegradable multi-block copolymers display high transfection efficiency in plasmid delivery with low cytotoxicity.
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申请公布号 |
US2003147958(A1) |
申请公布日期 |
2003.08.07 |
申请号 |
US20020061003 |
申请日期 |
2002.01.29 |
申请人 |
AHN CHEOL-HEE;CHAE SU YOUNG |
发明人 |
AHN CHEOL-HEE;CHAE SU YOUNG |
分类号 |
A61K47/34;A61K47/48;C12N15/87;(IPC1-7):A61K48/00;A61K9/14 |
主分类号 |
A61K47/34 |
代理机构 |
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代理人 |
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地址 |
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