发明名称 |
Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers |
摘要 |
A method is provided for increasing the permeability of skin or mucosal tissue to a topically or transdermally administered pharmacologically or cosmeceutically active peptide, polypeptide or protein. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the peptide, polypeptide or protein through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Formulations and drug delivery devices employing hydroxide-releasing agents as permeation enhancers are provided as well.
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申请公布号 |
US2003147943(A1) |
申请公布日期 |
2003.08.07 |
申请号 |
US20030349582 |
申请日期 |
2003.01.22 |
申请人 |
LUO ERIC C.;HSU TSUNG-MIN |
发明人 |
LUO ERIC C.;HSU TSUNG-MIN |
分类号 |
A61K9/00;A61K9/70;A61K31/137;A61K47/02;(IPC1-7):A61K38/21;A61K38/48;A61K38/19;A61K38/20 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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